Investigating Verbal Repetition in Persian-Speaking Patients with the Semantic Variant of Primary Progressive Aphasia Compared to Healthy Individuals
Abstract
Introduction: Language deficit is regarded as one of the most important hallmarks of primary progressive aphasia. This study aims to analyze the nature of verbal repetition ability in a group of patients suffering from the semantic variant of primary progressive aphasia and investigate their cognitive capability.
Materials and Methods: In this cross-sectional study, 12 patients of the semantic variant of primary progressive aphasia and 12 healthy individuals accomplished a set of tasks, including naming, word comprehension, digit span, repetition of multisyllabic single words, monosyllabic word span under similar or dissimilar phonological conditions, and sentence repetition.
Results: The patients exhibited some degree of impairment with diverse patterns in each task, although the accomplishment of the sentence repetition task was the most challenging activity for the primary progressive aphasic patients of the semantic variant. However, the healthy individuals performed well in all tasks.
Conclusion: The recognition of the quantity and quality of the cognitive deficit in the semantic variant of primary progressive aphasics can illuminate the nature of this disease and contribute to a better diagnosis of this disease. Furthermore, it can assist speech therapists and neuropsychologist to recruit appropriate therapies and employ better techniques for the diagnosis and cure of these patients.
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2. Wilson SM, Henry ML, Besbris M, Ogar JM, Dronkers NF, Jarrold W, et al. Connected speech production in three variants of primary progressive aphasia. Brain. 2010;133(7):2069-88.
3. Grossman M, Ash S. Primary progressive aphasia: a review. Neurocase. 2004;10(1):3-18.
4. Iaccarino L, Crespi C, Della Rosa PA, Catricala E, Guidi L, Marcone A, et al. The semantic variant of primary progressive aphasia: clinical and neuroimaging evidence in single subjects. PLoS One. 2015;10(3):e0120197.
5. Tan RH, Wong S, Kril JJ, Piguet O, Hornberger M, Hodges JR, et al. Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia. Brain. 2014;137(7):2065-76.
6. Leyton CE, Villemagne VL, Savage S, Pike KE, Ballard KJ, Piguet O, et al. Subtypes of progressive aphasia: application of the international consensus criteria and validation using β-amyloid imaging. Brain. 2011;134(10):3030-43.
7. Mesulam M-M, Wieneke C, Thompson C, Rogalski E, Weintraub S. Quantitative classification of primary progressive aphasia at early and mild impairment stages. Brain. 2012;135(5):1537-53.
8. Kertesz A, Davidson W, McCabe P, Takagi K, Munoz D. Primary progressive aphasia: diagnosis, varieties, evolution. Journal of the International Neuropsychological Society. 2003;9(5):710-9.
9. Leyton CE, Savage S, Irish M, Schubert S, Piguet O, Ballard KJ, et al. Verbal repetition in primary progressive aphasia and Alzheimer's disease. Journal of Alzheimer's Disease. 2014;41(2):575-85.
10. DeLeon J, Gottesman RF, Kleinman JT, Newhart M, Davis C, Heidler-Gary J, et al. Neural regions essential for distinct cognitive processes underlying picture naming. Brain. 2007;130(5):1408-22.
11. Forkel SJ, Rogalski E, Sancho ND, D'Anna L, Laguna PL, Sridhar J, et al. Anatomical evidence of an indirect pathway for word repetition. Neurology. 2020;94(6):e594-e606.
12. Kail R, Hall LK. Distinguishing short-term memory from working memory. Memory & cognition. 2001;29(1):1-9.
13. Baddeley A. Working memory: looking back and looking forward. Nature reviews neuroscience. 2003;4(10):829-39.
14. Baddeley A. Working memory: theories, models, and controversies. Annual review of psychology. 2012;63:1-29.
15. Camos V, Mora G, Barrouillet P. Phonological similarity effect in complex span task. Quarterly Journal of Experimental Psychology. 2013;66(10):1927-50.
16. Baddeley AD, Hitch GJ, Allen RJ. Working memory and binding in sentence recall. Journal of Memory and Language. 2009;61(3):438-56.
17. Polišenská K, Chiat S, Roy P. Sentence repetition: What does the task measure? International Journal of Language & Communication Disorders. 2015;50(1):106-18.
18. Klem M, Melby‐Lervåg M, Hagtvet B, Lyster SAH, Gustafsson JE, Hulme C. Sentence repetition is a measure of children's language skills rather than working memory limitations. Developmental science. 2015;18(1):146-54.
19. Beales A, Whitworth A, Cartwright J, Panegyres PK, Kane RT. Profiling sentence repetition deficits in primary progressive aphasia and Alzheimer’s disease: Error patterns and association with digit span. Brain and language. 2019;194:1-11.
20. Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76(11):1006-14.
21. Jafari S, Modarresszadeh A, Khatoonabadi AR, Hodges J, Ansari NN, Leyton C, et al. Development, cross-cultural adaptation, and psychometric characteristics of the persian progressive aphasia language scale in patients with primary progressive aphasia: A pilot study. Basic and clinical neuroscience. 2018;9(1):35.
22. Nilipour R, Pourshahbaz A, Ghoreyshi ZS. Reliability and validity of bedside version of Persian WAB (P-WAB-1). Basic and clinical neuroscience. 2014;5(4):253.
23. Ansari NN, Naghdi S, Hasson S, Valizadeh L, Jalaie S. Validation of a Mini-Mental State Examination (MMSE) for the Persian population: a pilot study. Applied neuropsychology. 2010;17(3):190-5.
24. Nilipour R, Pour Shahbaz A, Ghoreishi ZS, Yousefi A. Reliability and validity of Persian aphasia battery test. Iranian Journal of Ageing. 2016;10(4):182-91.
25. Savage S, Hsieh S, Leslie F, Foxe D, Piguet O, Hodges JR. Distinguishing subtypes in primary progressive aphasia: application of the Sydney language battery. Dementia and geriatric cognitive disorders. 2013;35(3-4):208-18.
26. Gorno-Tempini ML, Brambati SM, Ginex V, Ogar J, Dronkers NF, Marcone A, et al. The logopenic/phonological variant of primary progressive aphasia. Neurology. 2008;71(16):1227-34.
27. Wilde NJ, Strauss E, Tulsky DS. Memory span on the Wechsler scales. Journal of clinical and experimental neuropsychology. 2004;26(4):539-49.
28. Hodges JR, Patterson K. Semantic dementia: a unique clinicopathological syndrome. The Lancet Neurology. 2007;6(11):1004-14.
29. Rogers TT, Lambon Ralph MA, Garrard P, Bozeat S, McClelland JL, Hodges JR, et al. Structure and deterioration of semantic memory: a neuropsychological and computational investigation. Psychological review. 2004;111(1):205.
30. Hodges JR, Patterson K, Tyler LK. Loss of semantic memory: Implications for the modularity of mind. Cognitive Neuropsychology. 1994;11(5):505-42.
31. Macoir J, Lavoie M, Laforce Jr R, Brambati SM, Wilson MA. Dysexecutive symptoms in primary progressive aphasia: Beyond diagnostic criteria. Journal of geriatric psychiatry and neurology. 2017;30(3):151-61.
32. Foxe DG, Irish M, Hodges JR, Piguet O. Verbal and visuospatial span in logopenic progressive aphasia and Alzheimer's disease. Journal of the International Neuropsychological Society. 2013;19(3):247-53.
33. Miller HE, Cordella C, Collins JA, Ezzo R, Quimby M, Hochberg D, et al. Neural substrates of verbal repetition deficits in primary progressive aphasia. Brain Communications. 2021;3(1):fcab015.
2. Wilson SM, Henry ML, Besbris M, Ogar JM, Dronkers NF, Jarrold W, et al. Connected speech production in three variants of primary progressive aphasia. Brain. 2010;133(7):2069-88.
3. Grossman M, Ash S. Primary progressive aphasia: a review. Neurocase. 2004;10(1):3-18.
4. Iaccarino L, Crespi C, Della Rosa PA, Catricala E, Guidi L, Marcone A, et al. The semantic variant of primary progressive aphasia: clinical and neuroimaging evidence in single subjects. PLoS One. 2015;10(3):e0120197.
5. Tan RH, Wong S, Kril JJ, Piguet O, Hornberger M, Hodges JR, et al. Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia. Brain. 2014;137(7):2065-76.
6. Leyton CE, Villemagne VL, Savage S, Pike KE, Ballard KJ, Piguet O, et al. Subtypes of progressive aphasia: application of the international consensus criteria and validation using β-amyloid imaging. Brain. 2011;134(10):3030-43.
7. Mesulam M-M, Wieneke C, Thompson C, Rogalski E, Weintraub S. Quantitative classification of primary progressive aphasia at early and mild impairment stages. Brain. 2012;135(5):1537-53.
8. Kertesz A, Davidson W, McCabe P, Takagi K, Munoz D. Primary progressive aphasia: diagnosis, varieties, evolution. Journal of the International Neuropsychological Society. 2003;9(5):710-9.
9. Leyton CE, Savage S, Irish M, Schubert S, Piguet O, Ballard KJ, et al. Verbal repetition in primary progressive aphasia and Alzheimer's disease. Journal of Alzheimer's Disease. 2014;41(2):575-85.
10. DeLeon J, Gottesman RF, Kleinman JT, Newhart M, Davis C, Heidler-Gary J, et al. Neural regions essential for distinct cognitive processes underlying picture naming. Brain. 2007;130(5):1408-22.
11. Forkel SJ, Rogalski E, Sancho ND, D'Anna L, Laguna PL, Sridhar J, et al. Anatomical evidence of an indirect pathway for word repetition. Neurology. 2020;94(6):e594-e606.
12. Kail R, Hall LK. Distinguishing short-term memory from working memory. Memory & cognition. 2001;29(1):1-9.
13. Baddeley A. Working memory: looking back and looking forward. Nature reviews neuroscience. 2003;4(10):829-39.
14. Baddeley A. Working memory: theories, models, and controversies. Annual review of psychology. 2012;63:1-29.
15. Camos V, Mora G, Barrouillet P. Phonological similarity effect in complex span task. Quarterly Journal of Experimental Psychology. 2013;66(10):1927-50.
16. Baddeley AD, Hitch GJ, Allen RJ. Working memory and binding in sentence recall. Journal of Memory and Language. 2009;61(3):438-56.
17. Polišenská K, Chiat S, Roy P. Sentence repetition: What does the task measure? International Journal of Language & Communication Disorders. 2015;50(1):106-18.
18. Klem M, Melby‐Lervåg M, Hagtvet B, Lyster SAH, Gustafsson JE, Hulme C. Sentence repetition is a measure of children's language skills rather than working memory limitations. Developmental science. 2015;18(1):146-54.
19. Beales A, Whitworth A, Cartwright J, Panegyres PK, Kane RT. Profiling sentence repetition deficits in primary progressive aphasia and Alzheimer’s disease: Error patterns and association with digit span. Brain and language. 2019;194:1-11.
20. Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76(11):1006-14.
21. Jafari S, Modarresszadeh A, Khatoonabadi AR, Hodges J, Ansari NN, Leyton C, et al. Development, cross-cultural adaptation, and psychometric characteristics of the persian progressive aphasia language scale in patients with primary progressive aphasia: A pilot study. Basic and clinical neuroscience. 2018;9(1):35.
22. Nilipour R, Pourshahbaz A, Ghoreyshi ZS. Reliability and validity of bedside version of Persian WAB (P-WAB-1). Basic and clinical neuroscience. 2014;5(4):253.
23. Ansari NN, Naghdi S, Hasson S, Valizadeh L, Jalaie S. Validation of a Mini-Mental State Examination (MMSE) for the Persian population: a pilot study. Applied neuropsychology. 2010;17(3):190-5.
24. Nilipour R, Pour Shahbaz A, Ghoreishi ZS, Yousefi A. Reliability and validity of Persian aphasia battery test. Iranian Journal of Ageing. 2016;10(4):182-91.
25. Savage S, Hsieh S, Leslie F, Foxe D, Piguet O, Hodges JR. Distinguishing subtypes in primary progressive aphasia: application of the Sydney language battery. Dementia and geriatric cognitive disorders. 2013;35(3-4):208-18.
26. Gorno-Tempini ML, Brambati SM, Ginex V, Ogar J, Dronkers NF, Marcone A, et al. The logopenic/phonological variant of primary progressive aphasia. Neurology. 2008;71(16):1227-34.
27. Wilde NJ, Strauss E, Tulsky DS. Memory span on the Wechsler scales. Journal of clinical and experimental neuropsychology. 2004;26(4):539-49.
28. Hodges JR, Patterson K. Semantic dementia: a unique clinicopathological syndrome. The Lancet Neurology. 2007;6(11):1004-14.
29. Rogers TT, Lambon Ralph MA, Garrard P, Bozeat S, McClelland JL, Hodges JR, et al. Structure and deterioration of semantic memory: a neuropsychological and computational investigation. Psychological review. 2004;111(1):205.
30. Hodges JR, Patterson K, Tyler LK. Loss of semantic memory: Implications for the modularity of mind. Cognitive Neuropsychology. 1994;11(5):505-42.
31. Macoir J, Lavoie M, Laforce Jr R, Brambati SM, Wilson MA. Dysexecutive symptoms in primary progressive aphasia: Beyond diagnostic criteria. Journal of geriatric psychiatry and neurology. 2017;30(3):151-61.
32. Foxe DG, Irish M, Hodges JR, Piguet O. Verbal and visuospatial span in logopenic progressive aphasia and Alzheimer's disease. Journal of the International Neuropsychological Society. 2013;19(3):247-53.
33. Miller HE, Cordella C, Collins JA, Ezzo R, Quimby M, Hochberg D, et al. Neural substrates of verbal repetition deficits in primary progressive aphasia. Brain Communications. 2021;3(1):fcab015.
| Files | ||
| Issue | Vol 17 No 4 (2023) | |
| Section | Research Article(s) | |
| DOI | https://doi.org/10.18502/jmr.v17i4.13890 | |
| Keywords | ||
| Primary progressive aphasia Repetition Cognition | ||
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How to Cite
1.
Azad O. Investigating Verbal Repetition in Persian-Speaking Patients with the Semantic Variant of Primary Progressive Aphasia Compared to Healthy Individuals. jmr. 2023;17(4):412-419.
