Case Report

Resistance Training in Wilson Disease: A Case Study

Abstract

A 15-year-old boy was diagnosed with Wilson disease and referred to a physiotherapy clinic for treatment. He received daily physical therapy exercises with resistance training three times a week for 70 minutes for 8 weeks. The performance of daily activities was evaluated using the Persian version of the disabilities of the arm, shoulder, and hand (DASH) questionnaire. Upper limb muscle strength was assessed using a manual muscle strength test. The DASH questionnaire score decreased from 67.24 before treatment to 46.55 after 4 weeks and 36.20 after 8 weeks. In addition, shoulder flexion and extension are improved. The analysis of resistance exercises to facilitate distal muscles through the use of manual muscle tests showed an improvement in the strength of both hands. The present study suggests that regular physical therapy and exercise may help improve daily activity and muscle strength in Wilson disease.

Scheiber IF, Brůha R, Dušek P. Pathogenesis of Wilson disease. Handbook of Clinical Neurology. 2017; 142:43-55. [DOI:10.1016/B978-0-444-63625-6.00005-7] [PMID]
Van Nguyen H, Nguyen DN, Nguyen HT. A case of Wilson disease with the ATP7B mutation presenting movement disorders. Surgical Neurology International. 2021; 12. [DOI:10.25259/SNI_489_2021] [PMID] [PMCID]
Rani R, Rathia S, Kori V, Patel K. Wilson’S disease with ayurvedic approch-a case study. International Ayurvedic Medical Journal, India. 2020; 4910-4917. [DOI:10.46607/iamj5708102020]
Roman O.T. The effectiveness of cognitive-behaviour psychotherapy in Wilson’s disease: Single subject experiment. Journal of Psychological and Educational Research. 2021; 29 (1):140-153. [Link]
Collins CJ, Yi F, Dayuha R, Duong P, Horslen S, Camarata M, et al. Direct measurement of ATP7B peptides is highly effective in the diagnosis of Wilson disease. Gastroenterology. 2021; 160(7):2367-82. [DOI:10.1053/j.gastro.2021.02.052] [PMID] [PMCID]
Kalita J, Kumar V, Chandra S, Kumar B, Misra UK. Worsening of Wilson disease following penicillamine therapy. European Neurology. 2014; 71(3-4):126-31. [DOI:10.1159/000355276] [PMID]
Beinhardt S, Leiss W, Stättermayer AF, Graziadei I, Zoller H, Stauber R, et al. Long-term outcomes of patients with Wilson disease in a large Austrian cohort. Clinical Gastroenterology and Hepatology. 2014; 12(4):683-9. [DOI:10.1016/j.cgh.2013.09.025] [PMID]
Huster D, Kühne A, Bhattacharjee A, Raines L, Jantsch V, Noe J, et al. Diverse functional properties of Wilson disease ATP7B variants. Gastroenterology. 2012; 142(4):947-56. [DOI:10.1053/j.gastro.2011.12.048] [PMID] [PMCID]
Mousavi SJ, Parnianpour M, Abedi M, Askary-Ashtiani A, Karimi A, Khorsandi A, et al. Cultural adaptation and validation of the Persian version of the disabilities of the arm, shoulder and hand (DASH) outcome measure. Clinical Rehabilitation. 2008; 22(8):749-57. [DOI:10.1177/0269215508085821] [PMID]
Cuthbert SC, Goodheart Jr GJ. On the reliability and validity of manual muscle testing: A literature review. Chiropractic & Osteopathy. 2007; 15(1):4. [DOI:10.1186/1746-1340-15-4] [PMID] [PMCID]
Hislop HJ, Montgomery J. Daniels and Worthingham’s muscle testing: Techniques of manual examination. Amsterdam: Saunders/Elsevier; 2007. [Link]
Klingels K, De Cock P, Molenaers G, Desloovere K, Huenaerts C, Jaspers E, et al. Upper limb motor and sensory impairments in children with hemiplegic cerebral palsy. Can they be measured reliably? Disability and Rehabilitation. 2010; 32(5):409-16. [DOI:10.3109/09638280903171469] [PMID]
Brown B, Avers D, Daniels and Worthingham’s muscle testing: Techniques of manual examination and performance testing. Amsterdam: Elsevier; 2018. [Link]
Vispute A R, Kanase SB. Effect of proximal muscle strengthening on distal muscle facilitation in guillain barre syndrome. Journal of Evolution of Medical and Dental Sciences. 2020; 9 (37):2741-5. [DOI:10.14260/jemds/2020/595]
Nakhaie N, Nodehi-Moghadam A, Bakhshi E, Goghatin Alibazi R. Activation of shoulder girdle muscles during gripping task: A systematic review of literature. Physical Treatments-Specific Physical Therapy Journal. 2014; 4(1):3-8. [Link]
Files
IssueVol 17 No 2 (2023) QRcode
SectionCase Report(s)
DOI https://doi.org/10.18502/jmr.v17i2.12419
Keywords
Wilson disease Upper extremity Resistance training

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Chakeri Z, Talebian S. Resistance Training in Wilson Disease: A Case Study. jmr. 2023;17(2):212-218.