Prevalence of Dysphonia in Patients with COVID-19: A Systematic Review and Meta-Analysis
-
Alireza Aghaz
,
Arash Shahriyari
,
Shiva Panahiaboozar
,
Hossein Jadidi
,
Mohadeseh Khoshgoftar
,
Edris Choupani
,
Ehsan Hemmati
Abstract
Introduction: This study aimed to estimate the prevalence of dysphonia in patients with COVID-19.
Materials and Methods: English and Persian studies that reported dysphonia in patients with COVID-19 were included. Review and case report studies were excluded. We searched Web of Science, PubMed, Google Scholar, and Scopus from January 1, 2020, to July 15, 2021. The prevalence of dysphonia was obtained by combining the results and weighing the sample sizes in the corresponding studies. Heterogeneity was evaluated using the Cochran Q test and I2
Results: Of the 1830 articles identified, 7 studies (n=1410 patients) were included in the meta-analysis. The pooled prevalence of dysphonia was 31% (%95CI: 13%-48%). The prevalence rates of dysphonia in men and women with COVID-19 were 28.2% (%95CI: 14%-46%) and 32.8% (%95CI: 22%-45%), respectively.
Conclusion: Because of the design of the included studies, the reliability of the results is limited. There was notable heterogeneity in the data, not because of publication bias, but rather the small sample sizes or the heterogeneity of the COVID-19 disease. About one-third of patients with COVID-19 may have dysphonia as the only symptom. Therefore, one should even be careful in approaching those who have only dysphonia.
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25. Montori VM, Guyatt GH. Progress in evidence-based medicine. JAMA. 2008; 300(15):1814-6. [DOI:10.1001/jama.300.15.1814] [PMID]
2. Regan J, Walshe M, Lavan S, Horan E, Gillivan-Murphy P, Healy A, et al. post-extubation dysphagia and dysphonia amongst adults with COVID-19 in the Republic of Ireland: A prospective multi-site observational cohort study. Authorea. 2021; 1-12. [DOI:10.22541/au.161643490.01689099/v1]
3. Lechien JR, Chiesa-Estomba CM, Cabaraux P, Mat Q, Huet K, Harmegnies B, et al. Features of mild-to-moderate COVID-19 patients with dysphonia. Journal of Voice. 2020; 1-7. [DOI:10.1016/j.jvoice.2020.05.012]
4. Li MY, Li L, Zhang Y, Wang XS. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infectious Diseases of Poverty. 2020; 9(1):45. [DOI:10.1186/s40249-020-00662-x] [PMID] [PMCID]
5. Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. Review of the clinical characteristics of coronavirus disease 2019 (COVID-19). Journal of General Internal Medicine. 2020; 35(5):1545-9. [DOI:10.1007/s11606-020-05762-w] [PMID] [PMCID]
6. Elibol E. Otolaryngological symptoms in COVID-19. European Archives of Oto-Rhino-Laryngology. 2021; 278(4):1233-6. [DOI:10.1007/s00405-020-06319-7] [PMID]
7. Doblan A, Kaplama ME, Ak S, Basmacı N, Tarini EZ, Göktaş ŞE, et al. Cranial nerve involvement in COVID-19. American Journal of Otolaryngology. 2021; 42(5):102999. [DOI:10.1016/j.amjoto.2021.102999] [PMID] [PMCID]
8. Eltelety AM, Nassar AA. Dysphonia as the main presenting symptom of COVID-19: A case report. Kasr Al Ainy Medical Journal. 2020; 26(2):95-7. [DOI:10.4103/kamj.kamj_20_20]
9. Al-Ani RM, Rashid RA. Prevalence of dysphonia due to COVID-19 at Salahaddin General Hospital, Tikrit City, Iraq. American Journal of Otolaryngology. 2021; 42(5):103157. [DOI:10.1016/j.amjoto.2021.103157] [PMID] [PMCID]
10. Saniasiaya J, Kulasegarah J, Narayanan P. New-onset dysphonia: A silent manifestation of COVID-19. Ear, Nose, & Throat Journal. 2021 [Published Online]. [DOI:10.1177/0145561321995008] [PMID]
11. Asiaee M, Vahedian-Azimi A, Atashi SS, Keramatfar A, Nourbakhsh M. Voice quality evaluation in patients with COVID-19: An acoustic analysis. Journal of Voice. 2020; 1-7 [Published Online]. [DOI:10.1016/j.jvoice.2020.09.024] [PMID] [PMCID]
12. Cantarella G, Aldè M, Consonni D, Zuccotti G, Di Berardino F, Barozzi S, et al. Prevalence of dysphonia in non hospitalized patients with covid-19 in Lombardy, the Italian Epicenter of the Pandemic. Journal of Voice. 2021 [Published online]. [DOI:10.1016/j.jvoice.2021.03.009] [PMCID]
13. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020; 323(13):1239-42. [DOI:10.1001/jama.2020.2648] [PMID]
14. Deng SQ, Peng HJ. Characteristics of and public health responses to the coronavirus disease 2019 outbreak in China. Journal of Clinical Medicine. 2020; 9(2):575. [DOI:10.3390/jcm9020575] [PMID] [PMCID]
15. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021; 372:n71. [DOI:10.1136/bmj.n71] [PMID] [PMCID]
16. Margulis AV, Pladevall M, Riera-Guardia N, Varas-Lorenzo C, Hazell L, Berkman ND, et al. Quality assessment of observational studies in a drug-safety systematic review, comparison of two tools: The Newcastle-Ottawa scale and the RTI item bank. Clinical Epidemiology. 2014; 6:359-68. [DOI:10.2147/CLEP.S66677] [PMID] [PMCID]
17. Bennett JE, Dolin R, Blaser MJ, Dolin R. Mandell, douglas, and bennett’s principles and practice of infectious diseases. Amsterdam: Elsevier Health Sciences; 2014. https://www.google.com/books/edition/Mandell_Douglas_and_=en
18. Cohen SM, Kim J, Roy N, Asche C, Courey M. Prevalence and causes of dysphonia in a large treatment‐seeking population. The Laryngoscope. 2012; 122(2):343-8. [DOI:10.1002/lary.22426] [PMID]
19. Chamekh M, Deny M, Romano M, Lefèvre N, Corazza F, Duchateau J, et al. Differential susceptibility to infectious respiratory diseases between males and females linked to sex-specific innate immune inflammatory response. Frontiers in Immunology. 2017; 8:1806. [DOI:10.3389/fimmu.2017.01806] [PMID] [PMCID]
20. Al-Ani RM, Acharya D. Prevalence of anosmia and ageusia in patients with COVID-19 at a primary health center, Doha, Qatar. Indian Journal of Otolaryngology and Head & Neck Surgery. 2020; 1-7. [DOI:10.1007/s12070-020-02064-9] [PMID] [PMCID]
21. Husain Q, Kokinakos K, Kuo YH, Zaidi F, Houston S, Shargorodsky J. Characteristics of COVID-19 smell and taste dysfunction in hospitalized patients. American Journal of Otolaryngology. 2021; 42(6):103068. [DOI:10.1016/j.amjoto.2021.103068] [PMID] [PMCID]
22. Freni F, Meduri A, Gazia F, Nicastro V, Galletti C, Aragona P, et al. Symptomatology in head and neck district in coronavirus disease (COVID-19): A possible neuroinvasive action of SARS-CoV-2. American Journal of Otolaryngology. 2020; 41(5):102612. [DOI:10.1016/j.amjoto.2020.102612] [PMID] [PMCID]
23. Kosztyła-Hojna B, Moskal-Jasińska D, Kraszewska A, Łobaczuk-Sitnik A, Zdrojkowski M, Duchnowska E, et al. Verbal communication disorders in psychogenic dysphonia. Otolaryngologia Polska. 2019; 73(4):14-20. [DOI:10.5604/01.3001.0013.0999] [PMID]
24. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. 2020; 323(20):2052-9. [DOI:10.1001/jama.2020.6775] [PMID] [PMCID]
25. Montori VM, Guyatt GH. Progress in evidence-based medicine. JAMA. 2008; 300(15):1814-6. [DOI:10.1001/jama.300.15.1814] [PMID]
| Files | ||
| Issue | Vol 16 No 2 (2022) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/jmr.v16i2.9299 | |
| Keywords | ||
| Prevalence Dysphonia Voice COVID-19 Meta-analysis Review | ||
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How to Cite
1.
Aghaz A, Shahriyari A, Panahiaboozar S, Jadidi H, Khoshgoftar M, Choupani E, Hemmati E. Prevalence of Dysphonia in Patients with COVID-19: A Systematic Review and Meta-Analysis. jmr. 2022;16(2):130-136.
