Cardiac Rehabilitation Utilization in Birjand, Iran: Referral, Participation, and Completion Rates in an Underprivileged Area - A Retrospective Cohort Study
Abstract
Background: Cardiac rehabilitation (CR) is a cornerstone of secondary prevention following coronary revascularization; however, its utilization remains suboptimal in underserved regions. This study aimed to evaluate referral, participation, and completion rates of CR and their associated factors in Birjand, Iran.
Material and Methods: This retrospective cohort study included 758 consecutive patients undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) between April 2022 and May 2023. Data on demographics, insurance status, education level, and physician CR familiarity were collected using a structured checklist and phone follow-up. The CR program was defined as 36 supervised sessions. Multivariate logistic regression models were used to identify factors associated with referral, participation, and completion. All reported odds ratios were derived from fully adjusted models.
Results: Among 749 eligible patients, 197 (26.3%) were referred to CR, 103 (52.3% of referred) participated, and 69 (67.0% of participants) completed the program. Multivariate analysis showed that higher education was the strongest predictor of referral (OR = 9.50, 95% CI: 4.90–18.27, p < 0.001), followed by male gender (OR = 2.12, 95% CI: [1.00-4.49], p = 0.005). Furthermore, Physicians familiar with CR had approximately a 3-fold higher referral rate compared to less-familiar colleagues. Insurance coverage was significantly associated with completion of the program (78% of insured vs. 59% of uninsured completers, p = 0.018).
Conclusion: Referral is the main systemic barrier to cardiac rehabilitation utilization in this underprivileged region. Participation and completion among referred patients reflect a selected group with adequate access, highlighting the need for system‑level interventions focused on physician referral practices—particularly for women and less‑educated patients—and improved insurance coverage to enhance equitable CR access.
2. Manandi D, Brieger D, Redfern J, Tu Q, Briffa T, Hafiz N, Hyun K. Socioeconomic Variation in the Association Between Participation in Cardiac Rehabilitation and Clinical Outcomes in Patients With Acute Coronary Syndrome. Journal of Cardiopulmonary Rehabilitation and Prevention. 2026;46(1):67–75.
3. Voskuil M. Secondary prevention after acute and chronic coronary syndromes: are we still not there? Netherlands Heart Journal. 2025 Feb , 33:74–75.
4. Onuma OK. Making secondary prevention the primary focus for cardiovascular disease control. Journal of the American College of Cardiology. 2025 Feb 11;85(5):451-3.
5. Nordenskjöld AM, Qvarnström M, Wettermark B, Lindahl B. Adherence to secondary preventive treatment following myocardial infarction with and without obstructive coronary artery disease. PLoS One. 2025 May 23;20(5): e0324072.
6. Ramachandran HJ, Jiang Y, Tam WWS, Yeo TJ, Wang W. Effectiveness of home-based cardiac telerehabilitation as an alternative to Phase 2 cardiac rehabilitation of coronary heart disease: a systematic review and meta-analysis. European Journal of Preventive Cardiology. 2022;29(7):1017-43.
7. Beatty AL, Beckie TM, Dodson J, et al. A new era in cardiac rehabilitation delivery: research gaps, questions, strategies, and priorities. Circulation. 2023;147(3):254-66.
8. Taylor RS, Dalal HM, McDonagh ST. The role of cardiac rehabilitation in improving cardiovascular outcomes. Nature Reviews Cardiology. 2022;19(3):180-94.
9. Mbau L, Prabhakar PM, Khan Z. Effectiveness of Cardiac Rehabilitation Services in Low-and Middle-Income Countries: A Systematic Review. Cureus. 2023;15(12).
10. Sadeghi M, Turk Adawi K, Supervia M, et al. Availability and nature of cardiac rehabilitation by province in Iran: A 2018 update of ICCPR’s global audit. J Res Med Sci 2023;28:1.
11. Mirzaei Najmabadi A, Rahimi MS, Riahi SM, Kazemi T. Cardiac rehabilitation is necessary for patients: Providing experiences from the launch of cardiac rehabilitation in a deprived province in Iran. J Res Med Sci 2024;29:57.
12. Rodrigo SF, Van Exel HJ, Van Keulen N, Van Winden L, Beeres SL, Schalij MJ. Referral and participation in cardiac rehabilitation of patients following acute coronary syndrome; lessons learned. IJC Heart & Vasculature. 2021;36:100858.
13. Gómez González L, Supervia M, Medina-Inojosa JR, et al. Predictors of Rehabilitation Referral Among Cardiovascular Surgical Patients. Frontiers in Cardiovascular Medicine. 2022;9:848610.
14. Li S, Fonarow GC, Mukamal K, et al. Sex and racial disparities in cardiac rehabilitation referral at hospital discharge and gaps in long‐term mortality. Journal of the American Heart Association. 2018;7(8):e008088.
15. Thomas EE, Le Grande M, Phillips S, Cartledge S, Poulter R, Murphy BM. Predictors of Cardiac Rehabilitation Attendance and Completion: Analysis of 33,055 Patients from the Queensland Cardiac Outcomes Registry (2020–2022). Heart, Lung and Circulation. 2025 Jan 1;34(1):84-94.
16. Miralles-Resurreccion KV, Grace SL, Cuenza LR. Trends in cardiac rehabilitation enrollment post-coronary artery bypass grafting upon implementation of automatic referral in Southeast Asia: A retrospective cohort study. Journal of cardiovascular and thoracic research. 2022 Jun 28;14(2):84.
17.Soroush A, Heydarpour B, Komasi S, Saeidi M, Ezzati P. Barriers for the referral to outpatient cardiac rehabilitation: A predictive model including actual and perceived risk factors and perceived control. Annals of cardiac anaesthesia. 2018;21(3):249-54.
18. Moradi B, Maleki M, Esmaeilzadeh M, Abkenar HB. Physician-related factors affecting cardiac rehabilitation referral. The Journal of Tehran Heart Center. 2011;6(4):187.
19. Nalini M. Outpatient cardiac rehabilitation use after coronary bypass surgery in the west of Iran. Journal of cardiopulmonary rehabilitation and prevention. 2014;34(4):263-70.
20- Bryant J, Rubenfire M, Katona AM, et al. Increasing cardiac rehabilitation participation through a “Nearer to Home” patient referral program. Journal of Cardiopulmonary Rehabilitation and Prevention. 2021 Jan 1;41(1):E1-4.
21- Wang L, Liu J, Fang H, Wang X. Factors associated with participation in cardiac rehabilitation in patients with acute myocardial infarction: A systematic review and meta‐analysis. Clinical Cardiology. 2023 Nov;46(11):1450-7.
22- Salari A, Ebadollahian A, Parvaneh S, Fakhrmousavi A, Hasandokht T. Demographic and Social Factors Affecting Participation in Cardiac Rehabilitation: A Cross-Sectional Study. International Journal of Cardiovascular Practice. 2025 Jun;10(1).
23- Bakhshayeh S, Sarbaz M, Kimiafar K, Vakilian F, Eslami S. Barriers to participation in center-based cardiac rehabilitation programs and patients’ attitude toward home-based cardiac rehabilitation programs. Physiotherapy theory and practice. 2021 Jan 2.
24- Najafi M, Teimouri-Jervekani Z, Jamalian M, et al. Gender differences in cardiac rehabilitation participation and outcomes: an 18-year retrospective study in Iran. The Egyptian Heart Journal. 2024 Oct 4;76(1):133.
25. Thrush AH. Cardiac Rehabilitation in Abu Dhabi: A Retrospective Investigation of Program Delivery, Participants, and Factors Associated with Program Completion Utilizing a Hospital Registry. Journal of the Saudi Heart Association. 2023;35(3):235
26. Peacock JM, Styles E, Johnson S, et alA. Surveillance of the Initiation of, Participation in, and Completion of Cardiac Rehabilitation in Minnesota, 2017–2018. Preventing Chronic Disease. 2023 Apr 13;20:E24.
| Issue | Articles in Press | |
| Section | Research Article(s) | |
| Keywords | ||
| Cardiac rehabilitation; Referral; Patient participation; Treatment adherence | ||
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