Tehran University of Medical Sciences Journal of Modern Rehabilitation 2538-385X 18 1 2024 01 01 1 14 EN Seyyedeh Fatemeh Mousavi Baigi Department of Health Information Technology, School of Paramedical and Rehabilitation Science, Mashhad University of Medical Sciences, Mashhad, Iran. Masoumeh Sarbaz Department of Health Information Technology, School of Paramedical and Rehabilitation Science, Mashhad University of Medical Sciences, Mashhad, Iran. Davood Sobhani-Rad Department of Speech Therapy, School of Paramedical and Rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran. Atefeh Sadat Mousavi Department of Health Information Technology, School of Paramedical and Rehabilitation Science, Mashhad University of Medical Sciences, Mashhad, Iran. Fatemeh Dahmardeh Department of Speech Pathology, Paramedical Sciences Faculty, Mashhad University of Medical Sciences, Mashhad, Iran Khalil Kimiafar Department of Health Information Technology, School of Paramedical and Rehabilitation Science, Mashhad University of Medical Sciences, Mashhad, Iran. 2022 08 10 2022 09 21 Introduction: This study systematically evaluates the effect of telerehabilitation on improving physical activity, physical function, and quality of life (QoL) in individuals with multiple sclerosis (MS). Materials and Methods: Studies were obtained by searching the title, abstract, and keywords without time limit in the Scopus, PubMed, Embase, and Web of Science databases. The quality of the included studies was assessed using the Joanna Briggs institute checklist. The same checklist was used for data extraction. Results: A total of 16 eligible articles were found. In 12 studies, the results showed significant performance improvement, reduced fatigue, improved physical activity, and general balance in the telerehabilitation approach. Furthermore, of the 16 included studies, 5(31) reported an improvement in individuals’ QoL, two of which showed a significant improvement in the individuals’ QoL in the intervention group compared to the control group. Conclusion: The findings of this review showed that telerehabilitation services for MS individuals’ precautions are comparable to or better than conventional services. Telerehabilitation is an effective educational instrument to restitute and maintain physical activity and balance in individuals with MS; however, no considerable improvement in individuals’ QoL was reported. https://jmr.tums.ac.ir/index.php/jmr/article/view/721