Tehran University of Medical Sciences Journal of Modern Rehabilitation 2538-385X 16 4 2022 08 10 298 303 Karrar Albomahmood Department of Physical Therapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. Azadeh Shadmehr Department of Physical Therapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Reza Hadian Department of Physical Therapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. Shohreh Jalaie Department of Physical Therapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. Jameel Tahseen Department of Surgery, College of Medicine, University of Babylon, Babil, Iraq. Sara Fereydounnia Department of Physical Therapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. 2021 04 20 2021 06 12 Introduction: To demonstrate the effectiveness of extracorporeal shock wave therapy (ESWT) in treating active trigger points to relieve pain and increase range of motion (ROM) and improve the function of the cervical region in fewer sessions. Materials and Methods: In this single-group, pretest-posttest study, 15 participants with active myofascial trigger points (MTrPs) in the upper trapezius muscle took part. Before and after each treatment, visual analog scale (VAS), pressure pain threshold (PPT), neck disability index (NDI) questionnaire, and range of active contra lateral flexion (CLF) were assessed. Participants were given three treatments over a week, with at least a two-day break between them, and then all outcomes were evaluated. Results: The general results of this study demonstrate a significant reduction in pain perception in terms of VAS (P=0.0001), increased pressure pain threshold (P=0.0001), increased CLF of ROM (P=0.0001), and improved neck function by reduction of NDI (P=0.0001), after the third session of ESWT intervention in participants with MTrP in the upper trapezius muscle. Conclusion: It reveals that ESWT has positive effects on pain reduction, cervical range of motion, and cervical function in participants treated with MTrPs in the upper trapezius muscle. https://jmr.tums.ac.ir/index.php/jmr/article/view/434