Tehran University of Medical Sciences Journal of Modern Rehabilitation 2538-385X 16 2 2022 04 01 108 119 EN Sajjad Farashi Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Salman Khazaei Health Sciences and Technology Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran. Mohammad Rezaei Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. 2021 03 31 2021 06 17 Parkinson's Disease (PD) is a neurodegenerative disorder that causes movement and behavioral problems. Pharmacological advancements for preventing disease progression have limited success for many PD patients; therefore, supportive care is necessary. The advancement of the digital world and the revolution of computerized applications pave the way for a better understanding of PD and inventing technological apparatus for helping PD patients to provide them a more normal life. In this review, the most recent technological advancements regarding the rehabilitation, monitoring, and early prognosis of PD are presented. Furthermore, the possible neurological mechanisms responsible for the positive effects of technological-based interventions are discussed. https://jmr.tums.ac.ir/index.php/jmr/article/view/410