Tehran University of Medical Sciences Journal of Modern Rehabilitation 2538-385X 10 1 2016 08 28 7 12 EN Marzeyeh Mousai MSc, Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. Afsoon Hassani-Mehraban Associate Professor, Department of Occupational Therapy, School of Rehabilitation Sciences, Rehabilitation Research Center, Iran University of Medical Sciences, Tehran, Iran. Malahat Akbarfahimi Assistant Professor, Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences,Tehran, Iran. Seyed Masoud Nabavi Associate Professor, Department of Neurology, School of Medicine, Shahed Medical University, Tehran, Iran. 2016 08 28 2016 08 28 Introduction: Multiple sclerosis (MS) is one of the most common disabling diseases in young adults. Common manifestations include fatigue, bladder and bowel disorders, pain, mobility problems, and cognitive impairment. These symptoms seriously affect the activity of daily living (ADL) of people with MS. The purpose of this study to investigate relationship between disability severity and ADL in people with MS. Material and Methods: A total of 112 people with MS enrolled in this study. These people were evaluated by Barthel index, Mini Mental Status Examination, the Extended Disability Status Scale for ADL, cognitive ability and severity of disability. Results: In linear regression analysis, independence in ADL is the best of predictor (69%) of disability severity in people with MS. The Pearson correlation test between the severity of disability and independence in ADL showed a significant relationship. Conclusion: Independence in performing ADL can predict disability severity in people with MS. https://jmr.tums.ac.ir/index.php/jmr/article/view/2 https://jmr.tums.ac.ir/index.php/jmr/article/download/2/10