Tehran University of Medical Sciences Journal of Modern Rehabilitation 2538-385X 20 2 2026 04 01 184 198 Maryam Alizadeh Department of Speech Therapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. Azar Mehri Department of Speech Therapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. Shohreh Jalaie Department of Physiotherapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. Edythe A. Strand Mayo College of Medicine, Rochester, United States of America. & Mayo Clinic, Rochester, United States of America. 2025 10 20 2026 01 31 Introduction: Dynamic temporal and tactile cueing (DTTC) is a treatment method for childhood apraxia of speech (AOS), and its characteristics make it a suitable option for treating patients with AOS. Additionally, no documented treatment protocol has been published in Iran for the treatment of patients with AOS. This study protocol aims to investigate the efficacy of DTTC in the treatment of Persian-speaking patients with acquired AOS, who will be recruited using non-probability, convenience sampling. Materials and Methods: A single-subject study with multiple baseline designs across participants was designed to obtain detailed information about the intervention procedure on at least three participants’ performance, and a perceptual scoring system was introduced to measure the accuracy of treated and untreated words and phrases as a dependent variable. Results: The results of a visual analysis will be provided based for the assessment of participants at three phases of baseline, treatment, and follow-up, and the effect sizes will be reported. Conclusion: This study describes the first research investigating the efficacy of DTTC on the speech of AOS patients and the first treatment protocol for Persian-speaking patients with AOS. https://jmr.tums.ac.ir/index.php/jmr/article/view/1451