Tehran University of Medical Sciences Journal of Modern Rehabilitation 2538-385X 0 - 2025 11 11 1402 1402 Priyanka Gupta Department of Physical Rehabilitation and Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh, India Seveka Bali Department of Physical Rehabilitation and Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh, India Amrit Pal Sood Department of Physical Rehabilitation and Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh, India Amit Mital Department of Pediatrics, Shri Atal Bihari Vajpayee Government Medical College, Chhainsa, Faridabad, Haryana, India Priyanka Choudhary Department of Community Medicine, Shri Atal Bihari Vajpayee Government Medical College, Chhainsa, Faridabad, Haryana, India Sudhansu Baral Department of Physical Rehabilitation and Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh, India Somya Saxena Department of Physical Rehabilitation and Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh, India Reeta Upadhyay Department of Physical Rehabilitation and Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh, India Renu Suthar Department of Pediatrics, Post Graduate Institute of Medical Education & Research, Chandigarh, India 2025 08 20 2025 11 09 Background - Duchenne Muscular Dystrophy (DMD) is an inherited neuromuscular disorder caused by mutations in the dystrophin gene, leading to progressive muscle weakness. This study aimed to evaluate the efficacy of telerehabilitation in the improvement of pulmonary function in DMD patients. Materials and Methods - An interventional study was conducted among boys aged 5 to 12 years with DMD enrolled in the Pediatric Neurology clinic between September 2023 to February 2024. Telemedicine-based respiratory exercises were explained to the patients and their parents every 15 days for a 3 month-period, and patients were encouraged to do exercise for at least 5 days a week. Pulmonary function tests, including Forced Vital Capacity (FVC) and Forced Expiratory Volume in 1 second (FEV1), were recorded before and after intervention. Results –67 children participated in this study. There was significant improvement in forced vital capacity (FVC) [p value <0.001, Cohen’s d value=1.93] and forced expiratory volume in one second (FEV1) [p value <0.001, Cohen’s d value=1.06]. The FEV1/FVC ratio, a parameter that can be elevated in restrictive diseases, was also significantly decreased [p value <0.001, Cohen’s d value = -0.63]. For a one-unit increase in age, the FVC change after intervention was predicted to decrease significantly by 0.24 units, holding other variables constant. Conclusions: Telemedicine-based pulmonary rehabilitation for 3 months markedly improved the pulmonary function, thus concluding that this intervention is effective in improving the pulmonary function of DMD patients, and effectiveness is more if telerehabilitation is started at an early age. https://jmr.tums.ac.ir/index.php/jmr/article/view/1402