Tehran University of Medical Sciences Journal of Modern Rehabilitation 2538-385X 19 4 2025 07 22 381 393 EN Husnul Mubarak Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Andi Islam Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Andi Bintang Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Muhammad Massi Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Hening Putra Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Airlangga University, Surabaya, Indonesia. Jumraini Tammasse Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Susi Aulina Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Agussalim Bukhari Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Firdaus Hamid Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Andi Zainuddin Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. & Department of Public Health and Community Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. Edwin Pomada Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. 2025 01 22 2025 07 22 Introduction: Early post-stroke rehabilitation reduces disability and improves quality of life. However, limited access to rehabilitation facilities presents a significant challenge. Home-based telerehabilitation has emerged as a viable solution to reach distant stroke populations. Motor recovery relies on penumbral reorganization and restructuring. Brain-derived neurotrophic factor (BDNF) plays a crucial role in regulating synaptic plasticity. However, the impact of additional rehabilitation sessions on BDNF levels and motor function in post-stroke patients remains unexplored. Materials and Methods: A randomized controlled trial was conducted from June to September 2023, involving 50 patients with stroke. A medical history was assessed using a questionnaire, and motor function was evaluated using the Fugl-Meyer assessment (FMA). Blood samples were collected to measure BDNF levels. The intervention included prescribing home-based exercises using a telerehabilitation application on cell phones for 12 weeks. BDNF levels and FMA scores were reassessed at the end of the study. Results: Significant increases in BDNF and FMA scores were observed in the mobile-based telerehabilitation group. The increase in BDNF and FMA levels in the intervention group exceeded that of the control group. Conclusion: Mobile-based telerehabilitation is superior to conventional home exercise programs for delivering home-based therapeutic exercises. https://jmr.tums.ac.ir/index.php/jmr/article/view/1236