Tehran University of Medical Sciences Journal of Modern Rehabilitation 2538-385X 19 3 2025 03 12 265 277 Mohammadreza Karami Department of Health and Sport Medicine, Faculty of Sport Sciences, University of Tehran, Tehran, Iran. Aliasghar Jamehbozorgi Department of Occupational Therapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Parsa Salemi Department of Physiotherapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mehdi Rezaei Department of Orthotics and Prosthetics, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2025 01 10 2025 03 12 Introduction: Ankle sprains are the most common sports injuries. This study aims to assess the effects of six weeks of neuromuscular training on muscle strength, balance, range of motion (ROM), and proprioception in participants with ankle sprains. Materials and Methods: Seventeen semi-professional athletes with ankle sprains were randomly allocated to the intervention group (n=9) and the control group (n=8). The intervention group followed a prescribed neuromuscular training program, while the control group followed their normal training routine. Results: A significant difference was observed in the muscle strength of the invertor muscles before and after the training at an angular velocity of 60 °/s and before and after the training program at an angular velocity of 120 °/s in the intervention group (P<0.05). Also, a significant difference was observed between muscle strength of evertor muscles before and after a training program with an angular velocity of 60 °/s and before and after training, an angular velocity of 120 °/s in the intervention group (P<0.05). A significant difference was observed between the overall balance scores before and after training in the intervention group (P<0.05). A significant difference was observed in proprioception before and after training in the intervention group (P<0.05). No significant difference was observed in the ROM before and after training in the intervention group (P>0.05). Conclusion: Six weeks of neuromuscular training improved muscle strength, balance and proprioception in athletes with lateral ankle sprains (LASs). https://jmr.tums.ac.ir/index.php/jmr/article/view/1230